Our research focuses on cell-free DNA (cfDNA) and its potential use in laboratory diagnostics as a «liquid biopsy». More specifically, we are interested in the application of this approach to detect and monitor allograft injury in organ transplant recipients . Our ultimate aim is to translate research findings into clinically useful diagnostic tests that contribute to an improved monitoring and treatment of patients.
We work towards our research goal by developing analytical methods utilizing state-of-the-art genomics methods such as high-throughput sequencing and droplet digital PCR, and applying them to samples that we systematically collect from organ transplant recipients.
- PD Dr. med. et phil. Daniel Sidler (Department of Nephrology & Hypertension, Bern University Hospital)
- PD Dr. med et phil. Vanessa Banz (Department of Visceral Surgery & Medicine, Bern University Hospital)
- PD Dr. med et phil Tobias Grob (Institute of Pathology, University of Bern)
- Prof. Bruce Carleton and Prof. Colin Ross (University of British Columbia and BC Children's Hospital, Vancouver, BC, Canada, and Canadian Pharmacogenomics Network for Drug Safety)
Our research is supported by the Swiss National Science Foundation, Hemmi Stiftung and the Fondation Johanna Dürmüller-Bol.